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KMID : 0387720120230020169
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Korean Journal of Blood Transfusion
2012 Volume.23 No. 2 p.169 ~ p.172
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Detection of Anti-Lua in an Unexpected Antibody Screening Test: A Case Report and Literature Review
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Song Sae-Am
Oh Seung-Hwan
Park Tae-Sung
Son Hye-Soo
Sung Sung-Kyung
Lee Ja-Young
Jun Kyung-Ran
Shin Jeong-Hwan
Kim Hye-Ran
Lee Jeong-Nyeo
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Abstract
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Lutheran a antigen (Lua) is detected in 6 to 8% of Caucasians and Africans. In Korean and other Asian populations, it is very rare or nearly absent. Therefore, although Lua has a considerable immunizing capacity, sensitization to Lua is a rare event. Here we report on a rare case of anti-Lua in a 70 year-old female patient with Lu (a?/b＋) phenotype and review the relevant literature. Due to the paucity of Lua positive panel cells in antibody screening and identification tests, detection of this rare antibody to Lua antigen is not feasible. Therefore, we should keep in mind the possibility of the misleading false negative result in detection of antibody to this low incidence antigen.
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KEYWORD
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Lutheran blood group system, Anti-Lua alloantibody, Antibody screening test
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